Research
Hormonal
Transient reductions in fasting glucose were observed in participants with T2D, but these were not sustained and not significantly different from placebo at day 29.
While LY3537021 may reduce fasting glucose, the effects may not be long-lasting.
StrongQualifiesmedium confidence
Transient reductions in fasting glucose were observed in these participants, but the reductions were not sustained and not significantly different from placebo at day 29.
Why this rating
Based on the phase 1 randomized controlled trial design.
Source
Long-acting GIPR agonist LY3537021 reduces body weight and fasting blood glucose in patients with T2D: Preclinical development and phase 1 randomized ascending dose studies
William C. Roell et al. · Molecular Metabolism · 2025
DOI 10.1016/j.molmet.2025.102298
rctCited 2×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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