Research
Hormonal
Metformin was widely found to be weight-neutral with minimal effects on muscle mass.
Practitioners can consider Metformin as a weight-neutral option with minimal impact on muscle mass.
StrongSupportsmedium confidence
Metformin was widely found to be weight-neutral with minimal effects on muscle mass.
Why this rating
Based on the systematic review of studies.
Source
Effects of Blood-Glucose Lowering Therapies on Body Composition and Muscle Outcomes in Type 2 Diabetes: A Narrative Review
Ioana Bujdei-Tebeică et al. · Medicina · 2025
DOI 10.3390/medicina61081399
reviewCited 2×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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