Hormonal
Subcutaneous semaglutide increases the risk of gastrointestinal adverse events (nausea, diarrhea, vomiting) compared to placebo and other antidiabetic agents, but does not increase the risk of serious adverse events, hypoglycemia, acute pancreatitis, or diabetic retinopathy.
While semaglutide is effective, be aware that it commonly causes nausea, diarrhea, or vomiting, especially when starting or increasing the dose. These side effects are usually mild and temporary. Importantly, it does not appear to increase the risk of serious conditions like pancreatitis, hypoglycemia, or eye problems compared to other treatments.
For tolerability, semaglutide did not increase the incidence of adverse events (AEs) and serious adverse events (SAEs), severe or blood glucose (BG) confirmed hypoglycaemia, acute pancreatitis and diabetic retinopathy compared to placebo or active comparators, but did increase the risk of nausea, diarrhea and vomiting.
Why this rating
Meta-analysis of 17 RCTs.
Source
Efficacy and tolerability of the Subcutaneous Semaglutide for type 2 Diabetes patients: an updated systematic review and meta-analysis
Shanshan Hu et al. · Diabetology & Metabolic Syndrome · 2023
DOI 10.1186/s13098-023-01195-7
More from this paper
Related findings · Hormonal
- Initial treatment for type 2 diabetes should be a combination of metformin and either an SGLT-2 inhibitor or a GLP-1 receptor agonist to achieve cardiorenal protection, rather than monotherapy or older agents like sulfonylureas.Strong
- For patients with specific monogenic obesity syndromes (leptin deficiency, POMC/PCSK1/LEPR mutations), targeted pharmacotherapy (recombinant leptin or setmelanotide) is highly effective and should be prioritized, unlike in polygenic obesity.Strong
- Continued weekly administration of 2.4 mg subcutaneous semaglutide prevents weight regain and promotes further weight loss in adults with overweight or obesity, whereas switching to placebo results in significant weight regain.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →