Research
Hormonal
Subcutaneous semaglutide increases the risk of gastrointestinal adverse events (nausea, diarrhea, vomiting) compared to placebo and other antidiabetic agents, but does not increase the risk of serious adverse events, hypoglycemia, acute pancreatitis, or diabetic retinopathy.
While semaglutide is effective, be aware that it commonly causes nausea, diarrhea, or vomiting, especially when starting or increasing the dose. These side effects are usually mild and temporary. Importantly, it does not appear to increase the risk of serious conditions like pancreatitis, hypoglycemia, or eye problems compared to other treatments.
StrongQualifiesHIGH confidence
For tolerability, semaglutide did not increase the incidence of adverse events (AEs) and serious adverse events (SAEs), severe or blood glucose (BG) confirmed hypoglycaemia, acute pancreatitis and diabetic retinopathy compared to placebo or active comparators, but did increase the risk of nausea, diarrhea and vomiting.
Why this rating
Meta-analysis of 17 RCTs.
Source
Efficacy and tolerability of the Subcutaneous Semaglutide for type 2 Diabetes patients: an updated systematic review and meta-analysis
Shanshan Hu et al. · Diabetology & Metabolic Syndrome · 2023
Meta-analysis · 17 studiesCited 26×
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