Hormonal
Semaglutide (0.5-1.0 mg once-weekly subcutaneous) lowers HbA1c and reduces body weight more effectively than other common GLP-1 RAs (exenatide, dulaglutide, liraglutide) and SGLT-2 inhibitors (canagliflozin) in Type 2 Diabetes.
If you have Type 2 Diabetes, semaglutide (0.5-1.0 mg weekly) is a highly effective option that lowers blood sugar and promotes weight loss more effectively than several other common diabetes medications like exenatide, dulaglutide, or liraglutide. It can be used alone or combined with other drugs like metformin or insulin.
Semaglutide 1.0 mg achieved a greater HbA1c reduction vs. exenatide once weekly 2.0 mg (-1.5 vs. -0.9%); semaglutide 1.0 mg achieved a greater body weight reduction vs. exenatide once weekly 2.0 mg (-5.6 vs. -1.9 kg)
Why this rating
Based on multiple Phase III trials (SUSTAIN program) comparing semaglutide to other active drugs.
Source
Future perspectives in diabesity treatment: Semaglutide, a glucagon‑like peptide 1 receptor agonist (Review)
Mariana Cornelia Tilinca et al. · Experimental and Therapeutic Medicine · 2021
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