Hormonal
Semaglutide (0.5-1.0 mg once-weekly subcutaneous) lowers HbA1c and reduces body weight more effectively than other common GLP-1 RAs (exenatide, dulaglutide, liraglutide) and SGLT-2 inhibitors (canagliflozin) in Type 2 Diabetes.
If you have Type 2 Diabetes, semaglutide (0.5-1.0 mg weekly) is a highly effective option that lowers blood sugar and promotes weight loss more effectively than several other common diabetes medications like exenatide, dulaglutide, or liraglutide. It can be used alone or combined with other drugs like metformin or insulin.
Semaglutide 1.0 mg achieved a greater HbA1c reduction vs. exenatide once weekly 2.0 mg (-1.5 vs. -0.9%); semaglutide 1.0 mg achieved a greater body weight reduction vs. exenatide once weekly 2.0 mg (-5.6 vs. -1.9 kg)
Why this rating
Based on multiple Phase III trials (SUSTAIN program) comparing semaglutide to other active drugs.
Source
Future perspectives in diabesity treatment: Semaglutide, a glucagon‑like peptide 1 receptor agonist (Review)
Mariana Cornelia Tilinca et al. · Experimental and Therapeutic Medicine · 2021
DOI 10.3892/etm.2021.10601
More from this paper
- Semaglutide (2.4 mg once-weekly subcutaneous) significantly reduces body weight in adults with obesity or overweight with comorbidities compared to placebo.Strong
- Semaglutide (subcutaneous and oral) demonstrates cardiovascular safety (non-inferiority) and potential renal benefits in high-risk Type 2 Diabetes patients, though it may increase retinopathy complications.Strong
Related findings · Hormonal
- Initial treatment for type 2 diabetes should be a combination of metformin and either an SGLT-2 inhibitor or a GLP-1 receptor agonist to achieve cardiorenal protection, rather than monotherapy or older agents like sulfonylureas.Strong
- For patients with specific monogenic obesity syndromes (leptin deficiency, POMC/PCSK1/LEPR mutations), targeted pharmacotherapy (recombinant leptin or setmelanotide) is highly effective and should be prioritized, unlike in polygenic obesity.Strong
- Continued weekly administration of 2.4 mg subcutaneous semaglutide prevents weight regain and promotes further weight loss in adults with overweight or obesity, whereas switching to placebo results in significant weight regain.Strong
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