Hormonal
Overexpression of the LAT1 transporter in vitro paradoxically decreases protein synthesis levels and BCKDHα protein content.
This finding is from a cell study, not humans, so it doesn't change your training or diet today. However, it suggests that simply having more of a specific transporter (LAT1) doesn't automatically mean your muscles will build more protein. The body has complex regulatory mechanisms that might actually suppress synthesis if certain transporters are overexpressed artificially.
In C2C12 myoblasts, LAT1 protein overexpression caused a paradoxical decrease in protein synthesis levels (p = 0.002) and decrease in BCKDHα protein (p = 0.001).
Why this rating
Valid mechanistic study, but conducted on cell lines (C2C12 myoblasts), not human subjects, limiting direct clinical applicability.
Source
LAT1 Protein Content Increases Following 12 Weeks of Resistance Exercise Training in Human Skeletal Muscle
Paul A. Roberson et al. · Frontiers in Nutrition · 2021
DOI 10.3389/fnut.2020.628405
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