Research

Hormonal

Tirzepatide 10 mg was associated with a reduction in predicted 10-year risk of type 2 diabetes from 5.3% to 1.2%.

Practitioners may consider tirzepatide as an effective intervention for reducing diabetes risk in overweight or obese patients.

StrongSupportsmedium confidence
From baseline to week 52, the least square (LS) mean predicted T2D risk changed from 5.3% to 1.2% for tirzepatide 10 mg.
Lin Zhao et al. · Diabetes Obesity and Metabolism · 2025

Why this rating

Based on the randomized controlled trial design of the SURMOUNT-CN trial.

Source

Predicting 10‐year risk of type 2 diabetes in Chinese people with overweight or obesity treated with Tirzepatide: Post hoc analysis of <scp>SURMOUNT</scp> ‐ <scp>CN</scp> trial

Lin Zhao et al. · Diabetes Obesity and Metabolism · 2025

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