Research
Hormonal
GLP-1RA therapy was associated with a lower risk of major adverse limb events (MALE) in nondiabetic patients with PAD (HR: 0.22; 95% CI: 0.17–0.28; p < 0.001).
GLP-1RAs may reduce the risk of serious limb complications in patients with PAD who do not have diabetes.
StrongSupportsmedium confidence
GLP-1RA use was associated with lower risk of MALE (HR: 0.22; 95% CI: 0.17–0.28; p < 0.001).
Why this rating
Based on a large retrospective cohort study design.
Source
Impact of GLP-1 receptor agonists on cardiovascular outcomes in patients with peripheral artery disease without diabetes: A propensity score-matched analysis
Emmanuel Daniel et al. · Journal of Investigative Medicine · 2025
DOI 10.1177/10815589251393978
cohort · n=27110Cited 1×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- GLP-1RA use was associated with a lower risk of major adverse cardiovascular events (MACE) in nondiabetic patients with PAD (HR: 0.61; 95% CI: 0.57–0.66; p < 0.001).Strong
- GLP-1RA therapy was associated with a lower risk of all-cause mortality in nondiabetic patients with PAD (HR: 0.40; 95% CI: 0.35–0.46; p < 0.001).Strong
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