Mixed
In severely obese individuals, indexing estimated glomerular filtration rate (eGFR) to actual body surface area (BSA) rather than the standard 1.73m2 reveals renal hyperfiltration, which significantly improves following medical weight loss.
If you have severe obesity, your standard kidney function test (eGFR) might be misleadingly low because it doesn't account for your larger body size. This can hide early kidney stress (hyperfiltration). Ask your doctor if they can calculate your kidney function using your actual body surface area. This method often reveals higher kidney function that improves as you lose weight, providing a more accurate baseline for your health.
When eGFR is indexed to actual BSA, many subjects display evidence of renal hyperfiltration which improves with weight loss.
Why this rating
Observational study with a robust cohort (N=146) and longitudinal follow-up, but lacks a control group for the specific measurement technique.
Source
Severe obesity and the impact of medical weight loss on estimated glomerular filtration rate
Amy E. Rothberg et al. · PLoS ONE · 2020
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