Hormonal
Women with PCOS exhibit metabolic inflexibility (impaired substrate switching) comparable to women with Type 2 Diabetes, independent of BMI differences.
For women with PCOS, metabolic inflexibility is a core feature similar to Type 2 Diabetes, not just a side effect of being overweight. This means your body struggles to switch between burning fat and sugar efficiently. Focus on strategies that improve insulin sensitivity (like resistance training and managing carbohydrate timing) rather than just calorie restriction, as the underlying hormonal environment (androgens) drives this inflexibility.
Women with PCOS were less metabolically flexible compared to healthy women with obesity (p < 0.0001), normal BMI (p < 0.0001), but after controlling for glucose disposal rate, were similar to women with T2DM (p = 0.99).
Why this rating
Cross-sectional study with robust controls (hyperinsulinemic euglycemic clamp), but lacks randomization and long-term outcome data.
Source
Metabolic inflexibility in women with PCOS is similar to women with type 2 diabetes
Nicholas T. Broskey et al. · Nutrition & Metabolism · 2018
DOI 10.1186/s12986-018-0312-9
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