Research
Hormonal
Early treatment with the DPP-4 inhibitor, sitagliptin, did not lead to better glycemic control than placebo and did not prevent posttransplant diabetes (PTD).
Practitioners should reconsider the use of sitagliptin for preventing PTD in kidney transplant patients.
StrongRefutesmedium confidence
Therefore, the take-home message is that early treatment with sitagliptin for posttransplant hyperglycemia did not lead to better glycemic control than placebo and did not prevent PTD.
Why this rating
The claim is based on a randomized controlled trial.
Source
Prevention of Posttransplant Diabetes: A Complex Problem Without a Simple Solution
Justin Oveyssi et al. · Transplantation · 2022
DOI 10.1097/tp.0000000000004374
rct · n=61
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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