Research
Hormonal
Both medications exhibited favorable cardiovascular profiles, though gastrointestinal adverse events constitute the predominant tolerability concern.
While both tirzepatide and retatrutide may improve cardiovascular health, practitioners should monitor for gastrointestinal side effects.
StrongSupportsmedium confidence
Both medications exhibited favorable cardiovascular profiles, though gastrointestinal adverse events constitute the predominant tolerability concern.
Why this rating
Based on the systematic review of clinical evidence.
Source
TIRZEPATIDE AND RETATRUTIDE IN THE TREATMENT OF OBESITY AND TYPE 2 DIABETES MELLITUS: CURRENT EVIDENCE AND FUTURE DIRECTIONS. A SYSTEMATIC REVIEW OF CURRENT LITERATURE
Rafał Bednarczyk et al. · International Journal of Innovative Technologies in Social Science · 2026
systematic_review
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