Research
Hormonal
Individuals without diabetes were more likely to achieve ≥10% weight loss compared to individuals with T2D (21.4% vs. 0%).
Practitioners may consider the likelihood of achieving significant weight loss when prescribing tirzepatide based on diabetes status.
GoodSupportsmedium confidence
A ≥10% weight loss was achieved by 21.4% of individuals without diabetes compared with 0% of individuals with T2D.
Why this rating
The study is a prospective observational cohort study.
Source
Tirzepatide-induced Weight Loss in Overweight or Obese Midlife Adults with and without Type 2 Diabetes: A Real-world Comparative Cohort Study
Prabhat Kumar Agrawal et al. · Journal of Mid-life Health · 2026
DOI 10.4103/jmh.jmh_373_25
cohort · n=93
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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