Research
Hormonal
Current evidence does not support a single dominant mechanism for the efficacy of GLP-1 receptor agonists.
Practitioners should consider multiple factors influencing the effectiveness of GLP-1 receptor agonists.
StrongQualifiesmedium confidence
Current evidence does not support a single dominant mechanism; a combination of subtle effects may underlie the efficacy of these medications.
Why this rating
The claim is based on a critical review of existing evidence.
Source
GLP‐1 Receptor Agonists and Weight Loss: A Critical Review of Mechanisms
Giorgia Rutigliani et al. · Obesity Reviews · 2026
DOI 10.1111/obr.70148
review
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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