Research
Hormonal
Semaglutide reduces the composite of cardiovascular death, nonfatal myocardial infarction, or nonfatal stroke by 20% in adults with established cardiovascular disease.
GLP-1 therapies may also provide cardiovascular benefits, which is important for patient management.
StrongSupportsmedium confidence
semaglutide reduced the composite of cardiovascular death, nonfatal myocardial infarction, or nonfatal stroke by 20%.
Why this rating
Based on the SELECT trial with a large sample size.
Source
Reframing obesity as a chronic, multifactorial disease: Clinical implications of GLP-1–based therapies
Roopesh Jain · Advances in Biomedical and Health Sciences · 2026
DOI 10.4103/abhs.abhs_94_25
review · n=17604
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- GLP-1 receptor agonists and dual glucose-dependent insulinotropic polypeptide/GLP-1 receptor agonists provide clinically meaningful weight loss of approximately 15%–21% at 68–72 weeks in major trials.Strong
- Obesity should be framed as a chronic, multifactorial disease requiring comprehensive management strategies.Strong
Related findings · Hormonal
- Initial treatment for type 2 diabetes should be a combination of metformin and either an SGLT-2 inhibitor or a GLP-1 receptor agonist to achieve cardiorenal protection, rather than monotherapy or older agents like sulfonylureas.Strong
- For patients with specific monogenic obesity syndromes (leptin deficiency, POMC/PCSK1/LEPR mutations), targeted pharmacotherapy (recombinant leptin or setmelanotide) is highly effective and should be prioritized, unlike in polygenic obesity.Strong
- Continued weekly administration of 2.4 mg subcutaneous semaglutide prevents weight regain and promotes further weight loss in adults with overweight or obesity, whereas switching to placebo results in significant weight regain.Strong
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