Research
Hormonal
Triple agonists (GLP-1/GIP/Glucagon) like retatrutide achieve even greater weight loss (>24%) than dual agonists, likely due to the addition of glucagon receptor agonism which increases energy expenditure.
Triple-agonist injections like retatrutide (12 mg/week) are showing even higher weight loss rates (~24%) than current dual agonists in early trials. This is due to the addition of glucagon stimulation, which boosts energy expenditure. These are still in development and not yet widely approved for obesity.
GoodSupportsHIGH confidence
the synthetic triple GLP-1R/GIPR/GCGR agonist peptide retatrutide (12 mg once weekly by subcutaneous injection) achieved a weight reduction of 24% during a 48 week study... GCG promotes weight loss due to its anorexigenic effect and by increased energy expenditure
Why this rating
Based on Phase 2 trials (retatrutide), which are smaller than Phase 3 but show strong efficacy.
Source
Recent advances in peptide-based therapies for obesity and type 2 diabetes
Clifford J. Bailey et al. · Peptides · 2024
DOI 10.1016/j.peptides.2024.171149
narrative_reviewCited 20×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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