Macro partitioning
A low-carbohydrate diet (LCD) with carbohydrate intake restricted to <14% of total energy (approx. <50g/day) enables significant medication withdrawal and superior glycemic control compared to a low-fat diet (LFD) in type 2 diabetes patients, without increasing adverse events.
To achieve medication withdrawal in Type 2 Diabetes, restrict carbohydrates to under 50 grams per day (less than 14% of calories) while ensuring adequate protein and unsaturated fats. This approach, combined with regular exercise and clinical monitoring, allows for significant reduction in diabetes medications and better blood sugar control compared to traditional low-fat diets, without increasing the risk of hypoglycemia.
The LCD diet can decrease body weight, glycemic levels, MES, and lipid-lowering agents more than the LFD diet... Most participants in LCD group experienced a period of antiglycemic medication withdrawal... There was no significant difference in the incidence of hypoglycemia or ketoacidosis between the two groups
Why this rating
Randomized controlled trial with good adherence (90%) but short duration (6 months) and lack of a no-intervention control.
Source
A Low-Carbohydrate Diet Realizes Medication Withdrawal: A Possible Opportunity for Effective Glycemic Control
Yuxin Han et al. · Frontiers in Endocrinology · 2021
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