Macro partitioning
Genotype-based personalization of macronutrient intake (high-fat vs. high-carbohydrate) does not result in greater weight loss compared to genotype-discordant diets in individuals with overweight or obesity.
If you are overweight or obese, matching your diet to your genetic profile (e.g., high-fat vs. high-carb) does not provide a weight loss advantage over a diet that doesn't match your profile. Focus on sustainable caloric restriction and macronutrient choices you can maintain, as genetic testing for diet response currently offers no predictive benefit for weight loss magnitude.
Twelve-week WL did not differ between the genotype-concordant (−5.3 kg [SD:1.0]) and genotype-discordant diets (−4.8 kg [SD:1.1]; adjusted difference: −0.6 kg [95% CI: −2.1,0.9], p = 0.50). With the current ability to genotype participants as fat- or carbohydrate-responders, evidence does not support greater WL on genotype-concordant diets.
Why this rating
Randomized Clinical Trial (RCT) with blinded outcome assessors and a priori hypothesis testing.
Source
The Personalized Nutrition Study (POINTS): evaluation of a genetically informed weight loss approach, a Randomized Clinical Trial
Christoph Höchsmann et al. · Nature Communications · 2023
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