Research
Metabolic adaptation
Women reporting usually irregular or very irregular menstrual cycles had an increased risk for nonfatal or fatal coronary heart disease (CHD) with age-adjusted relative risks of 1.25 and 1.67, respectively.
Practitioners should consider menstrual cycle regularity as a potential risk factor for cardiovascular disease in women.
StrongSupportsmedium confidence
Compared with women reporting a history of very regular menstrual cycles, women reporting usually irregular or very irregular cycles had an increased risk for nonfatal or fatal CHD [age-adjusted relative risks (RR), 1.25 and 1.67, respectively; 95% confidence intervals (CI), 1.07-1.47 and 1.35-2.06, respectively].
Why this rating
Based on a large prospective cohort study.
Source
Menstrual Cycle Irregularity and Risk for Future Cardiovascular Disease
Caren G. Solomon et al. · The Journal of Clinical Endocrinology & Metabolism · 2002
DOI 10.1210/jcem.87.5.8471
cohort · n=82439Cited 510×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Increased risks for coronary heart disease associated with prior cycle irregularity remained significant after adjustment for body mass index and several potential confounders.Strong
- There was a nonsignificant increase in overall stroke risk associated with very irregular cycles (RR, 1.30; 95% CI = 0.97-1.74).Strong
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