Research
Hormonal
The relative risk for diagnosis of diabetes in the ramipril group was 0.60 when using hemoglobin A(1c) greater than 110% as a criterion.
This suggests that monitoring hemoglobin A(1c) could be beneficial in assessing diabetes risk in patients on ramipril.
StrongSupportsmedium confidence
In the ramipril group, the RR for diagnosis of diabetes and hemoglobin A(1c) greater than 110% was 0.60 (95% CI, 0.43-0.85).
Why this rating
Based on a large randomized controlled trial design.
Source
Ramipril and the Development of Diabetes
Salim Yusuf · JAMA · 2001
DOI 10.1001/jama.286.15.1882
rct · n=5720Cited 546×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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- Ramipril is associated with lower rates of new diagnosis of diabetes in high-risk individuals, with 3.6% in the ramipril group developing diabetes compared to 5.4% in the placebo group (RR, 0.66; P<.001).Strong
- Ramipril also showed a relative risk of 0.56 for the initiation of glucose-lowering therapy.Strong
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