Research
Hormonal
The highest breast cancer risk was seen in cancers positive for estrogen receptor (ER+) and progesterone receptor (PR+).
Understanding receptor status may help in assessing breast cancer risk in patients using unopposed estrogen.
GoodSupportsmedium confidence
The highest risk seen in cancers positive for estrogen receptor (ER+) and progesterone receptor (PR+).
Why this rating
Based on a prospective cohort study design.
Source
Unopposed Estrogen Therapy and the Risk of Invasive Breast Cancer
Wendy Y. Chen et al. · Archives of Internal Medicine · 2006
DOI 10.1001/archinte.166.9.1027
cohort · n=28835Cited 249×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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