Hormonal
A pragmatic prescribing pathway for liraglutide 3.0 mg using multiple stopping rules (≥5% weight loss at 16 weeks, ≥10% at 32 weeks, and ≥15% at 52 weeks) significantly increases the proportion of adults with obesity achieving ≥15% weight loss compared to standard specialist weight management services alone.
If you have a BMI of 35 or higher and conditions like high blood pressure or sleep apnea, ask your doctor about a specialized weight management program that includes liraglutide 3.0 mg. This medication is taken as a daily injection, starting at a low dose and increasing to 3 mg. A key part of this approach is 'stopping rules': if you don't lose enough weight at specific check-ups, the medication is stopped to save costs and avoid unnecessary side effects. This method helps ensure that only those who benefit continue treatment, leading to much better long-term weight loss results than lifestyle changes alone.
More intervention than control participants achieved WL ≥15% at 52 weeks [51/201 (25.4%) vs 6/93 (6.5%); odds ratio 5.18; 95% CI 2.09, 12.88; p < 0.0001].
Why this rating
Phase 4, multicentre, open-label, parallel-group, randomized controlled trial with a large sample size (n=392) and rigorous statistical analysis.
Source
Effectiveness of integrating a pragmatic pathway for prescribing liraglutide 3.0 mg in weight management services (STRIVE study): a multicentre, open-label, parallel-group, randomized controlled trial
Dimitris Papamargaritis et al. · The Lancet Regional Health - Europe · 2024
DOI 10.1016/j.lanepe.2024.100853
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