Macro partitioning
Replacing saturated fat (SFA) with polyunsaturated fat (PUFA) in the diet significantly reduces the risk of coronary heart disease (CHD) events, with a risk reduction of approximately 10% for every 5% of energy increased in PUFA intake.
To lower your risk of heart disease, swap saturated fats (found in animal products and some tropical oils) for polyunsaturated fats (found in vegetable oils like soybean, corn, and sunflower oils). Aim to increase your polyunsaturated fat intake by about 5% of your total daily calories. This substitution has been shown to reduce heart disease events by 10% for every 5% increase in polyunsaturated fat. You do not need to limit polyunsaturated fats to low levels; studies show benefits even at higher intakes.
These findings provide evidence that consuming PUFA in place of SFA reduces CHD events in RCTs... corresponding to 10% reduced CHD risk (RR = 0.90, 95% CI = 0.83–0.97) for each 5% energy of increased PUFA
Why this rating
This is a systematic review and meta-analysis of 8 randomized controlled trials (RCTs) with a total of 13,614 participants, providing high-quality evidence for clinical endpoints.
Source
Effects on Coronary Heart Disease of Increasing Polyunsaturated Fat in Place of Saturated Fat: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Dariush Mozaffarian et al. · PLoS Medicine · 2010
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