Hormonal
Deprescribing GLP-1 agonists in patients with Type 2 Diabetes does not result in weight regain or loss of glycemic control if the patient maintains Carbohydrate Restricted Nutrition Therapy (CRNT) supported by continuous remote care.
If you are taking a GLP-1 drug (like Ozempic or Wegovy) for Type 2 Diabetes, you may be able to stop the medication without regaining weight or losing blood sugar control, provided you switch to a strict low-carbohydrate diet (under 30g carbs/day) and maintain nutritional ketosis. This approach mimics the drug's hormonal effects on hunger and satiety. You should work with a healthcare provider to monitor your progress and determine if you are a candidate for deprescription.
Results of this real-world analysis demonstrate that GLP-1 can be discontinued without weight regain following initiation of successful co-therapy with carbohydrate restricted nutrition within this care model.
Why this rating
Real-world retrospective propensity-matched cohort study; high ecological validity but lower internal validity than RCTs.
Source
Impact of Glucagon-Like Peptide 1 Agonist Deprescription in Type 2 Diabetes in a Real-World Setting: A Propensity Score Matched Cohort Study
Amy L. McKenzie et al. · Diabetes Therapy · 2024
DOI 10.1007/s13300-024-01547-0
Related findings · Hormonal
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