Research
Hormonal
Genetically predicted higher childhood obesity, adult obesity, and increased fat-free mass are causally associated with a reduced risk of Brugada syndrome.
If you have Brugada syndrome, maintaining a BMI in the upper-normal range and increasing fat-free mass through resistance training may help reduce your risk. This contrasts with general population advice to lose weight, so consult your cardiologist about personalized weight management.
GoodSupportsHIGH confidence
This study suggests that genetically higher childhood/adult obesity and increased fat-free mass may reduce the risk of BrS.
Why this rating
Mendelian randomization reduces confounding, but the study relies on summary statistics and acknowledges potential residual pleiotropy.
Source
Multiple anthropometric characteristics and Brugada syndrome: A Mendelian randomization study
Sina Liu et al. · Medicine · 2025
DOI 10.1097/md.0000000000044990
cohort
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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