Hormonal
Tirzepatide enables a significant proportion of patients with type 2 diabetes to achieve normoglycemia (HbA1c < 5.7%) without clinically significant hypoglycemia, particularly when not combined with insulin or sulfonylureas.
Tirzepatide can help many patients with type 2 diabetes achieve normal blood sugar levels (HbA1c < 5.7%) without the high risk of dangerous low blood sugar episodes, especially if they are not taking insulin or sulfonylureas. This is a significant advantage over some other diabetes medications. Patients should still monitor their blood sugar as advised by their healthcare provider, but the risk of hypoglycemia is much lower with tirzepatide alone.
In the SURPASS program, up to 23–62% of participants achieved normoglycemia (HbA1c < 5.7%), vs. participants treated with semaglutide 1 mg (20%), insulin degludec (5%), and insulin glargine (3%). Normoglycemia was achieved without clinically significant hypoglycemia in 93.6–100% patients when tirzepatide was not combined with insulin (SURPASS 1–4) and in 85.9% patients when tirzepatide was added to insulin (SURPASS-5).
Why this rating
Based on phase 3 SURPASS clinical trial program data.
Source
Use of Tirzepatide in Adults with Type 2 Diabetes Mellitus: Scientific Evidence and Practical Aspects
Luis Alberto Vázquez et al. · Diabetes Therapy · 2024
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