Hormonal
Lasting remission of type 2 diabetes is not feasible in real-world settings due to the progressive nature of the disease, lack of consensus on definitions, and high rates of weight regain and treatment discontinuation.
Do not expect type 2 diabetes to be 'cured' or stay in remission without ongoing effort. Biological mechanisms will push your body to regain weight and increase hunger. Focus on sustainable management rather than a one-time fix, and maintain regular monitoring of cardiovascular and microvascular health even if your glucose levels are normal.
Is lasting remission feasible in the real-world setting? No! ... Natural history data show that diabetes is a progressive disease. ... Long-term remission is clearly difficult to achieve, and in addition we must also consider that substantial weight re-gain following cessation of a LED is commonly reported in trials.
Why this rating
Based on multiple large-scale studies (DiRECT, Look Ahead, SURMOUNT-2, STEP-2, SOS) and a whole-of-England database analysis, though it is a debate/opinion piece summarizing these.
Source
Is lasting remission feasible in the real-world setting? No!
Kamlesh Khunti · British Journal of Diabetes · 2024
DOI 10.15277/bjd.2024.453
Related findings · Hormonal
- Initial treatment for type 2 diabetes should be a combination of metformin and either an SGLT-2 inhibitor or a GLP-1 receptor agonist to achieve cardiorenal protection, rather than monotherapy or older agents like sulfonylureas.Strong
- For patients with specific monogenic obesity syndromes (leptin deficiency, POMC/PCSK1/LEPR mutations), targeted pharmacotherapy (recombinant leptin or setmelanotide) is highly effective and should be prioritized, unlike in polygenic obesity.Strong
- Continued weekly administration of 2.4 mg subcutaneous semaglutide prevents weight regain and promotes further weight loss in adults with overweight or obesity, whereas switching to placebo results in significant weight regain.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →