Research
Hormonal
Inhibiting miR-30e-5p using antagomirs reduces atherosclerosis in obese mouse models by restoring SLC7A11 expression and improving endothelial mitochondrial function.
While not yet a human treatment, this finding suggests that future therapies could target the specific signals fat cells send to blood vessels. For now, maintaining a healthy weight remains the most effective way to prevent these damaging signals from accumulating.
ModerateSupportsMEDIUM confidence
miR-30e-5p antagomir treatment reduced atherosclerosis in Apoe-/- and ob/ob mice... LNP-anti-miR-30e-5p administration decreased the circulatory level of glutamate and increased that of cystine as compared with LNP-Ctrl administration.
Why this rating
Strong mechanistic evidence in mice, but human clinical application is not yet established.
Source
Obesity Increases Atherosclerosis Susceptibility via Inter-tissue miR-30e-SLC7A11 Axis
Chen Wang et al. · bioRxiv (Cold Spring Harbor Laboratory) · 2025
DOI 10.1101/2025.03.06.641950
preprint
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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