Hormonal
Combining GLP-1 RAs with basal insulin provides superior glycemic management and cardiorenal protection compared to using either therapy alone, while mitigating the side effects of high-dose GLP-1 RAs.
If you are struggling to control your blood sugar with just a GLP-1 shot (like Ozempic) or just basal insulin, combining them is often the most effective strategy. New 'fixed-ratio' combination pens allow you to inject both medications in a single shot. This approach lowers your A1C more effectively than either drug alone, protects your heart and kidneys, and often reduces the side effects (like nausea) associated with high doses of GLP-1 RAs.
Numerous studies have shown that combined GLP-1 RA/basal insulin therapy provides effective glycemic management and cardiorenal protection, with reduced hypoglycemia risk
Why this rating
Supported by numerous randomized trials and fixed-ratio combination (FRC) product approvals.
Source
The Current and Future Role of Insulin Therapy in the Management of Type 2 Diabetes: A Narrative Review
Janet B. McGill et al. · Diabetes Therapy · 2024
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