Hormonal
Laparoscopic sleeve gastrectomy reduces the leptin-to-adiponectin ratio (LAR) in adults with severe obesity, which serves as a marker for improved insulin sensitivity and reduced cardiovascular risk.
For individuals with severe obesity considering sleeve gastrectomy, expect a significant improvement in insulin sensitivity, measured by the leptin-to-adiponectin ratio, within a year. This hormonal shift is a key driver of metabolic health improvement, potentially reducing the need for diabetes medications. While weight loss is substantial, the hormonal changes, particularly increased adiponectin, are critical for long-term metabolic benefits.
patients undergoing laparoscopic sleeve gastrectomy had a substantial reduction in their LAR after 12 months which was proportional to the amount of weight lost. This may indicate an improvement in insulin sensitivity and a reduction in cardiovascular risk.
Why this rating
Single-center prospective cohort with small sample size (n=17) and potential confounding from medication changes.
Source
The leptin to adiponectin ratio (LAR) is reduced by sleeve gastrectomy in adults with severe obesity: a prospective cohort study
Mohammed Rafey et al. · Scientific Reports · 2020
DOI 10.1038/s41598-020-73520-3
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