Hormonal
Multi-receptor incretin drugs significantly reduce systolic and diastolic blood pressure, with Tirzepatide and Mazdutide showing the most substantial reductions, particularly in non-diabetic populations.
If you have high blood pressure along with overweight or obesity, multi-receptor incretin drugs can help lower both systolic and diastolic blood pressure. This effect is often stronger in people without type 2 diabetes. Discuss with your doctor if these medications could help manage your blood pressure as part of your overall treatment plan.
Tirzepatide significantly reduced systolic blood pressure (MD: -6.69 mmHg... and diastolic blood pressure (MD: -3.73 mmHg... Non-diabetic participants showed more pronounced improvements in both weight and blood pressure.
Why this rating
Based on network meta-analysis of 15 studies.
Source
Comparative efficacy of incretin drugs on glycemic control, body weight, and blood pressure in adults with overweight or obesity and with/without type 2 diabetes: a systematic review and network meta-analysis
Song Liu et al. · Frontiers in Endocrinology · 2025
DOI 10.3389/fendo.2025.1513641
More from this paper
- Multi-receptor incretin drugs (Tirzepatide, Retatrutide, Mazdutide, Survodutide) produce substantial weight loss (>8kg) and glycemic control (HbA1c reduction >1%) in adults with overweight/obesity, with non-diabetic populations showing more pronounced effects than those with type 2 diabetes.Good
- Multi-receptor incretin drugs are associated with an increased risk of adverse events (primarily gastrointestinal) compared to placebo, but do not significantly increase the risk of serious adverse events.Good
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