Research
Hormonal
GLP-1 receptor agonists (GLP-1RAs) provide superior renal protection compared to insulin in early-stage diabetic kidney disease by reducing CD36 levels and urinary albumin excretion.
If you have type 2 diabetes and early kidney disease, ask your doctor about GLP-1 receptor agonists. They may protect your kidneys better than insulin while you continue taking metformin.
ModerateSupportsMEDIUM confidence
The main result was that GLP-1RAs significantly reduce CD36 and urinary albumin excretion in patients with early DKD, and was found to be superior to insulin in renal protection.
Why this rating
Based on a single-center prospective observational cohort study.
Source
Editorial: World diabetes day 2024: exploring mechanisms, innovations, and holistic approaches in diabetes care
Åke Sjöholm et al. · Frontiers in Endocrinology · 2026
DOI 10.3389/fendo.2026.1808396
narrative_review
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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