Hormonal
Weekly subcutaneous administration of GLP-1 receptor agonist (dulaglutide) significantly reduces HbA1c and body weight in patients with Type 2 Diabetes Mellitus who fail to adhere to low carbohydrate diet (LCD) or calorie restriction diet (CRD).
If you have Type 2 Diabetes and struggle to maintain a low-carb or calorie-restricted diet due to lifestyle, cognitive issues, or lack of support, ask your doctor about once-weekly GLP-1 receptor agonists like dulaglutide. This medication can significantly lower blood sugar (HbA1c) and help with weight loss even when dietary adherence is inconsistent. It is particularly useful for elderly patients or those with comorbidities who find daily management difficult.
Among them, we report and discuss here from various points of view... As a result, weight reduction and decreased HbA1c were found except for case-4... There was a tendency of weight reduction and decreased HbA1c value in 3 months.
Why this rating
Small case series (n=7) without a control group; results are observational within a clinical setting.
Source
Diabetic cases controlled with low carbohydrate diet (LCD) and GLP-1 receptor agonist (GLP-1 RA)
Masahiro Shirakawa et al. · Asploro Journal of Biomedical and Clinical Case Reports · 2019
DOI 10.36502/2019/asjbccr.6137
Related findings · Hormonal
- Initial treatment for type 2 diabetes should be a combination of metformin and either an SGLT-2 inhibitor or a GLP-1 receptor agonist to achieve cardiorenal protection, rather than monotherapy or older agents like sulfonylureas.Strong
- For patients with specific monogenic obesity syndromes (leptin deficiency, POMC/PCSK1/LEPR mutations), targeted pharmacotherapy (recombinant leptin or setmelanotide) is highly effective and should be prioritized, unlike in polygenic obesity.Strong
- Continued weekly administration of 2.4 mg subcutaneous semaglutide prevents weight regain and promotes further weight loss in adults with overweight or obesity, whereas switching to placebo results in significant weight regain.Strong
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