Research
Hormonal
Exercise alleviates chronic pain through neuroplasticity, endorphin release, and anti-inflammatory myokine secretion.
Regular exercise changes how your brain processes pain and releases natural painkillers (endorphins) and anti-inflammatory chemicals (myokines) from your muscles, helping you tolerate pain better.
GoodSupportsHIGH confidence
Engaging in consistent physical exercise amplifies the secretion of native opioids like endorphins, and it triggers the activation of suppressive neural pathways... exercise can facilitate anti-inflammatory responses, principally through the secretion of myokines...
Why this rating
Well-supported by cited literature in the review.
Source
A comprehensive guide to alleviating chronic pain through weight reduction and holistic exercise practices
Narendra Kumar Ahirwar et al. · The Journal of Community Health Management · 2023
DOI 10.18231/j.jchm.2023.020
narrative_review
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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