Macro partitioning
Adopting a low-carbohydrate, high-fat dietary pattern (defined as carbohydrate energy ≤40-49% and fat energy ≥34-40%) is associated with a significantly lower triglyceride-glucose (TyG) index, a surrogate marker for insulin resistance, primarily through the reduction of fasting triglyceride levels.
To potentially improve your insulin resistance markers, consider shifting your energy intake to include fewer carbohydrates (around 40-49% of calories) and more fat (around 34-40% of calories). This shift is linked to lower triglyceride levels, which is a key component of insulin resistance. Focus on whole food sources for these macronutrients.
A low-carbohydrate, high-fat diet was significantly associated with a lower triglyceride–glucose index; this association was primarily mediated by reductions in fasting triglyceride levels.
Why this rating
Large sample size (n=19,016) and rigorous statistical adjustments, but the cross-sectional design prevents causal inference.
Source
Low-carbohydrate, high-fat diet is inversely associated with the triglyceride–glucose index: evidence from NHANES 1999–2018
Wenya Zhu et al. · European journal of medical research · 2026
DOI 10.1186/s40001-026-04126-0
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