Macro partitioning
Moderate adherence to a nutrient pattern rich in unsaturated fatty acids and vitamin E is associated with lower all-cause and cancer mortality, whereas high adherence is associated with increased cerebrovascular disease mortality.
Include unsaturated fats (like those in fish and vegetable oils) and vitamin E sources in your diet, but avoid excessive consumption. The study suggests that moderate intake lowers cancer and all-cause mortality, while very high intake might increase stroke risk, possibly due to how these fats are prepared (e.g., deep-frying) or paired with other high-fat foods.
The second lowest quartile group of the Factor 2 (unsaturated fatty acid and vitamin E) score was associated with lower all-cause (HR 0.86, 95% CI 0.79–0.94) and cancer (HR 0.85, 95% CI 0.76–0.95) mortalities. On the other hand, a higher Factor 2 score was associated with greater cerebrovascular disease mortality (HR 1.57, 95% CI 1.03–2.40).
Why this rating
Same large cohort and rigorous statistical methods as N1, but the U-shaped curve adds complexity and potential for residual confounding.
Source
Nutrient patterns and mortality: results from the Japan Multi-Institutional Collaborative Cohort (J-MICC) study
Akari Matsuura et al. · Nutrition Journal · 2025
DOI 10.1186/s12937-025-01274-7
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