Hormonal
Genetic loci on chromosomes 3, 4, 9, 11, and 22 are linked to prediabetic metabolic phenotypes (fasting insulin, insulin action, and fasting glucose) in Pima Indians, suggesting a strong genetic basis for type 2 diabetes susceptibility in this population.
If you are of Pima Indian descent, you may have a higher genetic risk for type 2 diabetes due to specific gene variants affecting insulin handling. This doesn't mean you will get diabetes, but it does mean you should be proactive about monitoring your blood sugar and maintaining a healthy weight, as your body may be more sensitive to insulin resistance.
These analyses provided evidence for linkage at several chromosomal regions, including 3q21-24 linked to fasting plasma insulin concentration and in vivo insulin action, 4p15-q12 linked to fasting plasma insulin concentration, 9q21 linked to 2-h insulin concentration during oral glucose tolerance testing, and 22q12-13 linked to fasting plasma glucose concentration.
Why this rating
The study is a genomic scan with suggestive but not definitive linkage (LOD scores < 3.6), requiring replication.
Source
An autosomal genomic scan for loci linked to prediabetic phenotypes in Pima Indians.
Richard E. Pratley et al. · Journal of Clinical Investigation · 1998
DOI 10.1172/jci1850
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