Research
Hormonal
Postprandial hyperglycemia and glycemic variability are more strongly correlated with cardiovascular disease and mortality than fasting hyperglycemia alone, and controlling postprandial excursions reduces oxidative stress and hypoglycemia risk.
Don't just focus on fasting numbers. Large spikes after meals cause oxidative stress and increase heart disease risk. Managing post-meal glucose is crucial for long-term health.
GoodSupportsHIGH confidence
Epidemiological studies have shown that postprandial hyperglycemia rather than fasting hyperglycemia is more strongly correlated with CVD and all-cause mortality [62–64]. ... greater glycemic variability results in greater production of oxidative stress in patients with T2DM
Why this rating
Supported by epidemiological studies and CGMS data.
Source
Importance of Beta Cell Function for the Treatment of Type 2 Diabetes
Yoshifumi Saisho · Journal of Clinical Medicine · 2014
DOI 10.3390/jcm3030923
narrative_reviewCited 67×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Preserving or recovering endogenous beta cell function through reduction of beta cell workload (via lifestyle modification, metformin, or TZDs) is the primary therapeutic strategy for managing Type 2 Diabetes, as opposed to exogenous insulin supplementation which causes adverse effects.Good
- Lower baseline beta cell function (measured by postprandial C-peptide index) is strongly associated with poorer glycemic control, higher HbA1c, and greater glycemic variability, regardless of whether the patient is treated with oral agents or insulin.Good
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