Hormonal
GLP-1 receptor agonists (GLP1-RA) and SGLT2 inhibitors (SGLT2-i) are effective interventions for obesity-related cardiometabolic complications by reducing body weight and addressing pathophysiological derangements.
If lifestyle changes are insufficient, discuss GLP-1 RAs or SGLT2 inhibitors with your doctor. These medications are now recognized as essential tools for managing obesity and its heart/kidney risks, not just for diabetes.
Among the newer and available drugs, both the glucagon-like peptide-1 receptor (GLP1-RA) and the sodium-glucose cotransporter-2 inhibitors (SGLT2-i) can improve metabolic and CV risk factors by reducing body weight and acting on associated pathophysiological derangements.
Why this rating
Cited as 'innovative' and 'changing management' with strong clinical backing implied by their widespread adoption for T2DM and obesity.
Source
Adipocentric origin of the common cardiometabolic complications of obesity in the young up to the very old: pathophysiology and new therapeutic opportunities
Riccardo Sarzani et al. · Frontiers in Medicine · 2024
DOI 10.3389/fmed.2024.1365183
More from this paper
- Visceral adipose tissue (VAT) is the primary driver of cardiometabolic complications (hypertension, T2DM, dyslipidemia) through endocrine dysfunction, RAAS activation, and inflammation, rather than total body weight alone.Good
- Visceral fat accumulation activates the Renin-Angiotensin-Aldosterone System (RAAS) and Sympathetic Nervous System (SNS), leading to hypertension and sodium retention, independent of dietary salt intake.Good
Related findings · Hormonal
- Initial treatment for type 2 diabetes should be a combination of metformin and either an SGLT-2 inhibitor or a GLP-1 receptor agonist to achieve cardiorenal protection, rather than monotherapy or older agents like sulfonylureas.Strong
- For patients with specific monogenic obesity syndromes (leptin deficiency, POMC/PCSK1/LEPR mutations), targeted pharmacotherapy (recombinant leptin or setmelanotide) is highly effective and should be prioritized, unlike in polygenic obesity.Strong
- Continued weekly administration of 2.4 mg subcutaneous semaglutide prevents weight regain and promotes further weight loss in adults with overweight or obesity, whereas switching to placebo results in significant weight regain.Strong
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