Hormonal
Weight loss interventions induce significant but small changes in DNA methylation (DNAm) across the genome, and baseline DNAm levels at specific loci (e.g., TNF-α, LEP, CLOCK, PER2) can predict the magnitude of weight loss response.
Your body's epigenetic markers (DNA methylation) change when you lose weight, and your starting levels might predict how much weight you'll lose. While these changes are small on a genome-wide scale, specific markers like TNF-α and LEP show promise as predictors. This suggests personalized medicine may eventually use these markers to tailor weight loss strategies, but for now, standard interventions (diet/exercise/surgery) remain the primary lever.
Weight loss is associated with significant but small changes in DNAm across the genome, and weight loss outcome is associated with individual differences in baseline DNAm at several genomic locations.
Why this rating
Based on a systematic review of 25 longitudinal intervention studies, but the authors note the need for further validation with robust design and adequate power.
Source
A systematic review of studies of DNA methylation in the context of a weight loss intervention
Lucia Aronica et al. · Epigenomics · 2017
DOI 10.2217/epi-2016-0182
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