Research
Hormonal
Semaglutide administration (1-2 mg weekly) produces significant weight loss (median 13.3% at 6 months) in adults with obesity, with efficacy maintained even at lower maintenance doses (1 mg).
Semaglutide is a highly effective treatment for obesity, producing significant weight loss even at lower maintenance doses. It requires a weekly injection and is most effective when combined with lifestyle counseling. Patients should be aware of potential gastrointestinal side effects, which are usually mild.
ModerateSupportsMEDIUM confidence
This retrospective study demonstrated the significant effectiveness of semaglutide for weight loss, even at lower than approved maintenance doses, combined with a good safety profile.
Why this rating
Real-world retrospective observational study; lacks randomization and control arm, introducing potential confounders.
Source
A Real-World Study of the Effectiveness and Safety of Semaglutide for Weight Loss
Ploutarchos Tzoulis et al. · Cureus · 2024
DOI 10.7759/cureus.59558
cohort · n=40Cited 13×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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