Research

Hormonal

Omitting initial glucose-lowering drug treatment (GLDT) in newly diagnosed type 2 diabetes is associated with a higher 5-year risk of major adverse cardiovascular events (MACE), primarily mediated by lower initiation of statins and renin-angiotensin system inhibitors (RASi), even in patients achieving glycemic remission.

If you have newly diagnosed type 2 diabetes, even if you manage to normalize your blood sugar through diet and exercise (remission), you may still be at higher risk for heart attacks or strokes if you avoid glucose-lowering drugs. This is likely because avoiding these drugs also means you are less likely to be prescribed essential heart-protective medications like statins or blood pressure drugs. Ensure your doctor prescribes appropriate cardiovascular prevention strategies regardless of your glycemic status.

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Compared with well-controlled individuals on GLDT, individuals not on initial GLDT had a higher 5 year risk of MACE, even among those achieving remission of type 2 diabetes. This may be related to lower use of statins and RASi.
Alexander Christian Falkentoft et al. · Diabetologia · 2023

Why this rating

Large cohort study (n=14,221) using high-quality national registers with robust statistical adjustment and mediation analysis.

Source

Risk of first-time major cardiovascular event among individuals with newly diagnosed type 2 diabetes: data from Danish registers

Alexander Christian Falkentoft et al. · Diabetologia · 2023

DOI 10.1007/s00125-023-05977-6

cohort · n=14221Cited 13×
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DOI resolved against Crossref · corpus check 2026-06-10

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