Hormonal
Lowering blood glucose levels reverses glucose toxicity, thereby restoring beta-cell insulin secretion and enabling complete or partial remission of type 2 diabetes.
If you have Type 2 Diabetes, high blood sugar actively suppresses your pancreas's ability to make insulin. This suppression is often reversible. By aggressively lowering your blood glucose levels—through medication, intensive insulin therapy, or dietary changes—you can remove this 'glucose toxicity.' This allows your remaining beta-cells to recover function, potentially leading to remission where you no longer need medication. This is most likely if you have not had diabetes for many years and still have some beta-cell mass left.
This process, called glucose toxicity, has a major inhibitory effect on insulin secretion. This beta-cell dysfunction can be reversed by therapies that reduce glucose levels. Thus, it is becoming increasingly apparent that an opportunity exists to produce a complete or partial remission for T2D
Why this rating
The paper is a perspective/review citing multiple clinical studies (Cerasi, Wang, Retnakaran, Purnell) and animal models, but lacks a single primary RCT itself.
Source
Induction of remission in diabetes by lowering blood glucose
Gordon C. Weir et al. · Frontiers in Endocrinology · 2023
DOI 10.3389/fendo.2023.1213954
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