Hormonal
Higher doses of dulaglutide (4.5 mg) provide additional blood pressure reduction compared to 1.5 mg, but this additional benefit is primarily driven by greater weight loss rather than enhanced weight-independent mechanisms.
Increasing your dulaglutide dose from 1.5 mg to 4.5 mg may lower your blood pressure a bit more, but this extra benefit comes mostly from losing more weight, not from a stronger direct effect on your blood vessels. If you are not losing enough weight on 1.5 mg, the higher dose might help your BP by helping you lose more weight.
Dulaglutide 4.5 mg demonstrated an effect on reduction in SBP and pulse pressure beyond that of dulaglutide 1.5 mg which was primarily weight mediated.
Why this rating
Based on mediation analysis of AWARD-11 and indirect comparisons.
Source
Weight-dependent and weight-independent effects of dulaglutide on blood pressure in patients with type 2 diabetes
Keith C. Ferdinand et al. · Cardiovascular Diabetology · 2023
DOI 10.1186/s12933-023-01775-x
Related findings · Hormonal
- Initial treatment for type 2 diabetes should be a combination of metformin and either an SGLT-2 inhibitor or a GLP-1 receptor agonist to achieve cardiorenal protection, rather than monotherapy or older agents like sulfonylureas.Strong
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