Hormonal
Bariatric surgery (Roux-en-Y gastric bypass) significantly reduces circulating microvesicles (MVs) of monocyte and endothelial origin, specifically those expressing the CD36 scavenger receptor, within three months post-surgery.
For patients undergoing Roux-en-Y gastric bypass, significant reductions in inflammatory vascular markers (specifically CD36-bearing microvesicles from monocytes and endothelial cells) occur within just three months. This suggests that the surgery rapidly alleviates endothelial stress and low-grade inflammation associated with obesity, potentially reducing long-term cardiovascular risk beyond just weight loss.
Significant reductions were observed for the total MVs (− 66.55%, p = 0.0017) and MVs of monocyte (− 36.11%, p = 0.0056) and endothelial (− 40.10%, p = 0.0007) origins... significant reductions were observed for CD36-bearing MVs of monocyte (− 60.04%, p = 0.0192) and endothelial (− 54.93%, p = 0.04) origin.
Why this rating
Small sample size (n=20), single-arm pre-post design, short follow-up (3 months), and potential antibody binding artifacts noted by authors.
Source
Bariatric surgery reduces CD36-bearing microvesicles of endothelial and monocyte origin
Jaco Botha et al. · Nutrition & Metabolism · 2018
DOI 10.1186/s12986-018-0309-4
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