Hormonal
Pitavastatin 4mg daily increases the risk of new-onset diabetes in people with HIV, but this effect is clinically significant primarily in individuals with multiple baseline metabolic risk factors (obesity, pre-diabetes, or metabolic syndrome).
If you have HIV and are considering statins for heart health, discuss your metabolic risk factors (weight, blood sugar) with your doctor. If you are healthy weight and have normal blood sugar, your risk of developing diabetes from the statin is very low. If you have existing metabolic risks, your doctor may monitor your blood sugar more closely or suggest lifestyle interventions to mitigate this small risk.
A clinically significant effect of pitavastatin on DM was seen primarily among those with multiple risk factors for DM at entry.
Why this rating
Large, global, randomized, double-blind, placebo-controlled trial (REPRIEVE) with long follow-up.
Source
Diabetes Risk Factors in People With HIV Receiving Pitavastatin Versus Placebo for Cardiovascular Disease Prevention
Kathleen V. Fitch et al. · Annals of Internal Medicine · 2024
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