Hormonal
Exogenous testosterone administration (200 mg/week) does not alter whole-body energy expenditure, substrate oxidation, or skeletal muscle metabolic gene expression during a severe energy deficit in healthy men.
If you are a healthy man in a calorie deficit and exercising heavily, taking testosterone will not change how your body burns fat or carbs compared to not taking it. It helps preserve muscle mass, but it does not boost your metabolism or fat loss. Focus on your exercise volume and calorie intake for metabolic adaptations.
These data demonstrate that increased physical activity and not exogenous testosterone administration is the primary determinate of whole-body and skeletal muscle metabolic adaptations during diet- and exercise-induced energy deficit.
Why this rating
Randomized, double-blind, placebo-controlled trial with rigorous metabolic measurement (whole-room calorimetry) and muscle biopsies, though limited to young healthy men.
Source
Metabolic Adaptations and Substrate Oxidation are Unaffected by Exogenous Testosterone Administration during Energy Deficit in Men
Lee M. Margolis et al. · Medicine & Science in Sports & Exercise · 2022
DOI 10.1249/mss.0000000000003089
Related findings · Hormonal
- Initial treatment for type 2 diabetes should be a combination of metformin and either an SGLT-2 inhibitor or a GLP-1 receptor agonist to achieve cardiorenal protection, rather than monotherapy or older agents like sulfonylureas.Strong
- For patients with specific monogenic obesity syndromes (leptin deficiency, POMC/PCSK1/LEPR mutations), targeted pharmacotherapy (recombinant leptin or setmelanotide) is highly effective and should be prioritized, unlike in polygenic obesity.Strong
- Continued weekly administration of 2.4 mg subcutaneous semaglutide prevents weight regain and promotes further weight loss in adults with overweight or obesity, whereas switching to placebo results in significant weight regain.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →