Research
Hormonal
SGLT-2 inhibitors reduce the risk of worsening heart failure and cardiovascular death in patients with heart failure with reduced ejection fraction (HFrEF), regardless of diabetes status.
If you have heart failure with a weak pumping heart (HFrEF), SGLT-2 inhibitors (like Jardiance or Farxiga) are now a standard part of treatment. They reduce hospitalizations and death, even if you don't have diabetes. They help your heart pump more efficiently.
StrongSupportsVERY_HIGH confidence
Findings of DAPA-HF were consistent in patients regardless of the presence or absence of T2DM.
Why this rating
Based on DAPA-HF and EMPEROR-Reduced trials.
Source
Obesity 2021: Current Clinical Management of a Chronic, Serious Disease
Kushner · The Journal of Family Practice · 2021
DOI 10.12788/jfp.0221
narrative_reviewCited 4×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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