Hormonal
Beta-amyrin acetate, a compound derived from the medicinal fungus Poria cocos, acts as a putative antagonist of the Neuropeptide Y1 receptor (Y1R) by binding to the orthosteric site with high affinity, potentially inhibiting feeding behavior associated with obesity.
Beta-amyrin acetate is a specific chemical compound found in the fungus Poria cocos. Current research is purely computational (computer simulations), predicting it might block a specific brain receptor (Y1R) involved in hunger. There is no human dosing protocol or clinical evidence yet; do not use this as a weight loss treatment based on this paper alone.
PC12 beta-Amyrin acetate... were identified as candidate compounds due to their high affinities (-12.2... kcal...), high drug-likeness and low toxicity profiles... highlighting the feasibility and possible development of PC12 beta-Amyrin acetate as a future Y1R inhibitor.
Why this rating
The evidence is based entirely on in silico molecular docking and dynamics simulations, lacking in vivo or clinical validation.
Source
Poria cocos compounds targeting neuropeptide Y1 receptor (Y1R) for weight management: A computational ligand- and structure-based study with molecular dynamics simulations identified beta-amyrin acetate as a putative Y1R inhibitor
Ann Rann Wong et al. · PLoS ONE · 2023
DOI 10.1371/journal.pone.0277873
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