Macro partitioning
High intake of food rich in saturated fat is not independently associated with subclinical atherosclerosis (measured by carotid intima-media thickness) or its progression in high-risk European adults after adjusting for lifestyle and demographic confounders.
For individuals at high risk of cardiovascular disease, simply reducing saturated fat intake may not be sufficient to reduce subclinical atherosclerosis markers like carotid intima-media thickness. Focus on overall lifestyle factors, including physical activity, smoking cessation, and managing other risk factors, as the isolated effect of saturated fat on this specific measure was not significant in this high-risk population.
High intake of saturated fats was not independently associated with subclinical atherosclerosis. Moreover, we did not identify any significant genetic-dietary fat interactions in relation to risk of subclinical atherosclerosis.
Why this rating
Large multicenter cohort (n=3,407), longitudinal design (30 months), rigorous genetic screening, but limited by self-reported dietary assessment.
Source
Intake of food rich in saturated fat in relation to subclinical atherosclerosis and potential modulating effects from single genetic variants
Federica Laguzzi et al. · Scientific Reports · 2021
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