Hormonal
In Japanese subjects, obesity (higher BMI) reduces the numerical incretin effect more significantly than glucose intolerance (T2D or IGT status).
If you have Type 2 Diabetes or pre-diabetes, focus on weight management to improve your body's natural hormonal response to food. In Japanese populations, losing weight improves the 'incretin effect' (how your gut signals your pancreas to make insulin) more effectively than just managing blood sugar numbers alone.
We demonstrate that in Japanese subjects, obesity has a greater effect than glucose tolerance on the numerical incretin effect
Why this rating
Randomized controlled physiological study with clear statistical significance (p=0.012) for the correlation between BMI and incretin effect, though sample size is small (n=28).
Source
The integrated incretin effect is reduced by both glucose intolerance and obesity in Japanese subjects
Akihiro Hamasaki et al. · Frontiers in Endocrinology · 2024
DOI 10.3389/fendo.2024.1301352
Related findings · Hormonal
- Initial treatment for type 2 diabetes should be a combination of metformin and either an SGLT-2 inhibitor or a GLP-1 receptor agonist to achieve cardiorenal protection, rather than monotherapy or older agents like sulfonylureas.Strong
- For patients with specific monogenic obesity syndromes (leptin deficiency, POMC/PCSK1/LEPR mutations), targeted pharmacotherapy (recombinant leptin or setmelanotide) is highly effective and should be prioritized, unlike in polygenic obesity.Strong
- Continued weekly administration of 2.4 mg subcutaneous semaglutide prevents weight regain and promotes further weight loss in adults with overweight or obesity, whereas switching to placebo results in significant weight regain.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →